IMPACT OF NUTRITION ON HEALTH OUTCOMES

The literature strongly documents that nutritional interventions can have profound impacts on health outcomes. Yet one of the challenges with current research in this area is that many researchers use the standard pharmacological model (studying one molecule at a time) for establishing efficacy of nutrition. Nutritional factors, however, do not work in isolation; in fact, the opposite is true. A complex interplay of micronutrients, vitamins, minerals, and macronutrients within foods, and nutrients work in concert to impact health.

BONE BROTH

This area is being updated.

 

FERMENTED FOOD

This area is being updated.

 

FUNCTIONAL FOOD

Adams JB, Audhya T, McDonough-Means S, Rubin RA, Quig D, Geis E, et al. Effect of a vitamin/mineral supplement on children and adults with autism. BMC Pediatr. 2011;11:111.

Ahmed T, Haque R, Shamsir Ahmed AM, Petri WA, Jr., Cravioto A. Use of metagenomics to understand the genetic basis of malnutrition. Nutr Rev. 2009;67 Suppl 2:S201-6.

Bengmark S. Gut microbiota, immune development and function. Pharmacol Res. 2013;69(1):87-113.

Biltagi MA, Baset AA, Bassiouny M, Kasrawi MA, Attia M. Omega-3 fatty acids, vitamin C and Zn supplementation in asthmatic children: a randomized self-controlled study. Acta Paediatr. 2009;98(4):737-42.

Bland JS. Psychoneuro-nutritional medicine: an advancing paradigm. Altern Ther Health Med. 1995;1(2):22-7.

Bradley R, Oberg EB, Calabrese C, Standish LJ. Algorithm for complementary and alternative medicine practice and research in type 2 diabetes. J Altern Complement Med. 2007 Jan;13(1):159–75.

Buccigrossi V, Nicastro E, Guarino A. Functions of intestinal microflora in children. Curr Opin Gastroenterol. 2013;29(1):31-8.

Caramia G. [Childhood feeding, chronic-degenerative disease in adults, and nutrigenomics]. Pediatr Med Chir. 2007;29(6):309-20.

Chen K, Zhang X, Li TY, Chen L, Wei XP, Qu P, et al. Effect of vitamin A, vitamin A plus iron and multiple micronutrient-fortified seasoning powder on infectious morbidity of preschool children. Nutrition. 2011;27(4):428-34.

Critchfield JW, van Hemert S, Ash M, Mulder L, Ashwood P. The potential role of probiotics in the management of childhood autism spectrum disorders. Gastroenterol Res Pract. 2011;2011:161358.

D’Adamo CR, Miller RR, Shardell MD, Orwig DL, Hochberg MC, Ferrucci L, et al. Higher serum concentrations of dietary antioxidants are associated with lower levels of inflammatory biomarkers during the year after hip fracture. Clin Nutr. 2012;31(5):659-65.

D’Adamo E, Marcovecchio ML, Giannini C, de Giorgis T, Chiavaroli V, Chiarelli F, et al. Improved oxidative stress and cardio-metabolic status in obese prepubertal children with liver steatosis treated with lifestyle combined with Vitamin E. Free Radic Res. 2013;47(3):146-53.

da Costa Baptista IP, Accioly E, de Carvalho Padilha P. Effect of the use of probiotics in the treatment of children with atopic dermatitis; a literature review. Nutr Hosp. 2013;28(1):16-26.

DeBusk R, Sierpina VS, Kreitzer MJ. Applying functional nutrition for chronic disease prevention and management: bridging nutrition and functional medicine in 21st century healthcare. Explore (NY). 2011;7(1):55-7.

Dura-Trave T, Gallinas-Victoriano F. Caloric and nutrient intake in children with attention deficit hyperactivity disorder treated with extended-release methylphenidate: analysis of a cross-sectional nutrition survey. JRSM Open. 2014;5(2):2042533313517690.

Gow RV, Hibbeln JR, Parletta N. Current evidence and future directions for research with omega-3 fatty acids and attention deficit hyperactivity disorder. Curr Opin Clin Nutr Metab Care. 2015;18(2):133-8.

Holick MF. The D-lightful vitamin D for child health. JPEN J Parenter Enteral Nutr. 2012;36(1 Suppl):9S-19S.

Investigators M-EN. The MAL-ED study: a multinational and multidisciplinary approach to understand the relationship between enteric pathogens, malnutrition, gut physiology, physical growth, cognitive development, and immune responses in infants and children up to 2 years of age in resource-poor environments. Clin Infect Dis. 2014;59 Suppl 4:S193-206.

Kane AV, Dinh DM, Ward HD. Childhood malnutrition and the intestinal microbiome. Pediatr Res. 2015;77(1-2):256-62.

Kabasakalis A, Kalitsis K, Nikolaidis MG, Tsalis G, Kouretas D, Loupos D, et al. Redox, iron, and nutritional status of children during swimming training. J Sci Med Sport. 2009;12(6):691-6.

Kapka-Skrzypczak L, Niedzwiecka J, Cyranka M, Kruszewski MK, Skrzypczak M, Wojtyla A. [Nutrigenomics – perspectives of personalized nutrition]. Pediatr Endocrinol Diabetes Metab. 2011;17(4):222-6.

Karakula H, Opolska A, Kowal A, Domanski M, Plotka A, Perzynski J. [Does diet affect our mood? The significance of folic acid and homocysteine]. Pol Merkur Lekarski. 2009;26(152):136-41.

Kellow NJ, Coughlan MT, Reid CM. Metabolic benefits of dietary prebiotics in human subjects: a systematic review of randomised controlled trials. Br J Nutr. 2014;111(7):1147-61.

Kidd PM. Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids. Altern Med Rev. 2007;12(3):207-27.

Klein EG, Lytle LA, Chen V. Social ecological predictors of the transition to overweight in youth: results from the Teens Eating for Energy and Nutrition at Schools (TEENS) study. J Am Diet Assoc. 2008;108(7):1163-9.

Lau FC, Bagchi M, Sen C, Roy S, Bagchi D. Nutrigenomic analysis of diet-gene interactions on functional supplements for weight management. Curr Genomics. 2008;9(4):239-51.

Luoto R, Kalliomaki M, Laitinen K, Delzenne NM, Cani PD, Salminen S, et al. Initial dietary and microbiological environments deviate in normal-weight compared to overweight children at 10 years of age. J Pediatr Gastroenterol Nutr. 2011;52(1):90-5.

Magrone T, Jirillo E. Childhood obesity: immune response and nutritional approaches. Front Immunol. 2015;6:76.

Maher P. Methylglyoxal, advanced glycation end products and autism: is there a connection? Med Hypotheses. 2012;78(4):548-52.

McCloud E, Papoutsakis C. A medical nutrition therapy primer for childhood asthma: current and emerging perspectives. J Am Diet Assoc. 2011;111(7):1052-64.

Minich DM, Bland JS. Dietary management of the metabolic syndrome beyond macronutrients. Nutr Rev. 2008;66(8):429-44.

Minich DM, Bland JS. Personalized lifestyle medicine: relevance for nutrition and lifestyle recommendations. ScientificWorldJournal. 2013;2013:129841.

Nimni ME, Han B, Cordoba F. Are we getting enough sulfur in our diet? Nutr Metab (Lond). 2007;4:24.

Oh SY, Chung J, Kim MK, Kwon SO, Cho BH. Antioxidant nutrient intakes and corresponding biomarkers associated with the risk of atopic dermatitis in young children. Eur J Clin Nutr. 2010;64(3):245-52.

Patrick RP, Ames BN. Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism. FASEB J. 2014;28(6):2398-413.

Prior PL, Galduroz JC. (N-3) Fatty acids: molecular role and clinical uses in psychiatric disorders. Adv Nutr. 2012;3(3):257-65.

Schiltz B, Minich DM, Lerman RH, Lamb JJ, Tripp ML, Bland JS. A science-based, clinically tested dietary approach for the metabolic syndrome. Metab Syndr Relat Disord. 2009;7(3):187-92.

Simopoulos AP. Genetic variants in the metabolism of omega-6 and omega-3 fatty acids: their role in the determination of nutritional requirements and chronic disease risk. Exp Biol Med (Maywood). 2010;235(7):785-95.

Switzeny OJ, Mullner E, Wagner KH, Brath H, Aumuller E, Haslberger AG. Vitamin and antioxidant rich diet increases MLH1 promoter DNA methylation in DMT2 subjects. Clin Epigenetics. 2012;4(1):19.

Trivedi MS, Shah JS, Al-Mughairy S, Hodgson NW, Simms B, Trooskens GA, et al. Foodderived opioid peptides inhibit cysteine uptake with redox and epigenetic consequences. J Nutr Biochem. 2014;25(10):1011-8.

Van den Driessche M, Veereman-Wauters G. Functional foods in pediatrics. Acta Gastroenterol Belg. 2002;65(1):45-51.

Verlaet AA, Noriega DB, Hermans N, Savelkoul HF. Nutrition, immunological mechanisms and dietary immunomodulation in ADHD. Eur Child Adolesc Psychiatry. 2014;23(7):519-29.

Waterland RA, Jirtle RL. Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition. 2004;20(1):63-8.

Whittaker F. Rheumatoid remedies: a collection of more than 70 pages of nutritional and drug-free options to promote recovery from rheumatoid arthritis and associated inflammatory diseases. 1st ed. Kaitaia, N.Z.: Dancing Lion Press; 2009. 84 p. P.

 

RAW MILK

Alfvén T, Braun-Fahrländer C, Brunekreef B, von Mutius E, Riedler J, Scheynius A, van Hage M, Wickman M, Benz MR, Budde J, Michels KB, Schram D, Ublagger E, Waser M, Pershagen G; PARSIFAL study group. Allergic diseases and atopic sensitization in children related to farming and anthroposophic lifestyle–the PARSIFAL study. Allergy. 2006 Apr;61(4):414-21.

Barnes M, Cullinan P, Athanasaki P, MacNeill S, Hole AM, Harris J, Kalogeraki S, Chatzinikolaou M, Drakonakis N, Bibaki-Liakou V, Newman Taylor AJ, Bibakis I. Crete: does farming explain urban and rural differences in atopy? Clin Exp Allergy. 2001 Dec;31(12):1822-8.

Christian Bieli, MD, Waltraud Eder, MD, Remo Frei, MSc, Charlotte Braun-Fahrlander, MD, Walt Klimecki, PhD, Marco Waser, PhD, Josef Riedler, MD, Erika von Mutius, MD, MSc, Annika Scheynius, MD, PhD, Go¨ ran Pershagen, MD, PhD, Gert Doekes, PhD, Roger Lauener, MD, Fernando D. Martinez, MD, and the PARSIFAL study group. A polymorphism in CD14 modifies the effect of farm milk consumption on allergic diseases and CD14 gene expression. The Journal of Allergy and Clinical Immunology 120(6):1308-15. December 2007.

Loss G, Depner M, Ulfman LH, van Neerven RJ, Hose AJ, Genuneit J, Karvonen AM, Hyvärinen A, Kaulek V, Roduit C, Weber J, Lauener R, Pfefferle PI, Pekkanen J, Vaarala O, Dalphin JC, Riedler J, Braun-Fahrländer C, von Mutius E, Ege MJ; PASTURE study group. Consumption of unprocessed cow’s milk protects infants from common respiratory infections. J Allergy Clin Immunol. 2015 Jan;135(1):56-62. doi: 10.1016/j.jaci.2014.08.044. Epub 2014 Oct 19.

Loss G, Bitter S, Wohlgensinger J, Frei R, Roduit C, Genuneit J, Pekkanen J, Roponen M, Hirvonen MR, Dalphin JC, Dalphin ML, Riedler J, von Mutius E, Weber J, Kabesch M, Michel S, Braun-Fahrländer C, Lauener R; PASTURE study group. Prenatal and early-life exposures alter expression of innate immunity genes: the PASTURE cohort study. J Allergy Clin Immunol. 2012 Aug;130(2):523-30.e9. doi: 10.1016/j.jaci.2012.05.049.

Perkin MR. Unpasteurized milk: health or hazard? Clin Exp Allergy. 2007 May;37(5):627-30.

Perkin MR, Strachan DP. Which aspects of the farming lifestyle explain the inverse association with childhood allergy? J Allergy Clin Immunol. 2006 Jun;117(6):1374-81.

Radon K, Windstetter D, Eckart J, Dressel H, Leitritz L, Reichert J, Schmid M, Praml G, Schosser M, von Mutius E, Nowak D. Farming exposure in childhood, exposure to markers of infections and the development of atopy in rural subjects. Clin Exp Allergy. 2004 Aug;34(8):1178-83.

Riedler J, Braun-Fahrländer C, Eder W, Schreuer M, Waser M, Maisch S, Carr D, Schierl R, Nowak D, von Mutius E; ALEX Study Team. Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet. 2001 Oct 6;358(9288):1129-33.

Tremonte P, Tipaldi L, Succi M, Pannella G, Falasca L, Capilongo V, Coppola R, Sorrentino E. J Dairy Sci. Raw milk from vending machines: Effects of boiling, microwave treatment, and refrigeration on microbiological quality. 2014;97(6):3314-20. doi: 10.3168/jds.2013-7744. Epub 2014 Apr 3.

Waser M, Michels KB, Bieli C, Flöistrup H, Pershagen G, von Mutius E, Ege M, Riedler J, Schram-Bijkerk D, Brunekreef B, van Hage M, Lauener R, Braun-Fahrländer C; PARSIFAL Study team. Inverse association of farm milk consumption with asthma and allergy in rural and suburban populations across Europe. Clin Exp Allergy. 2007 May;37(5):661-70.

 

VITAMIN/MINERAL STATUS

Adams JB, Audhya T, McDonough-Means S, Rubin RA, Quig D, Geis E, et al. Effect of a vitamin/mineral supplement on children and adults with autism. BMC Pediatr. 2011;11:111.

Alabdali A, Al-Ayadhi L, El-Ansary A. A key role for an impaired detoxification mechanism in the etiology and severity of autism spectrum disorders. Behav Brain Funct. 2014;10:14.

Assa A, Vong L, Pinnell LJ, Avitzur N, Johnson-Henry KC, Sherman PM. Vitamin D deficiency promotes epithelial barrier dysfunction and intestinal inflammation. J Infect Dis. 2014;210(8):1296-305.

Back O, Blomquist HK, Hernell O, Stenberg B. Does vitamin D intake during infancy promote the development of atopic allergy? Acta Derm Venereol. 2009;89(1):28-32.

Basit S. Vitamin D in health and disease: a literature review. Br J Biomed Sci. 2013;70(4):161-72.

Biltagi MA, Baset AA, Bassiouny M, Kasrawi MA, Attia M. Omega-3 fatty acids, vitamin C and Zn supplementation in asthmatic children: a randomized self-controlled study. Acta Paediatr. 2009;98(4):737-42.

Bonnot O, Inaoui R, Raffin-Viard M, Bodeau N, Coussieu C, Cohen D. Children and adolescents with severe mental illness need vitamin D supplementation regardless of disease or treatment. J Child Adolesc Psychopharmacol. 2011;21(2):157-61.

Bradley R, Oberg EB, Calabrese C, Standish LJ. Algorithm for complementary and alternative medicine practice and research in type 2 diabetes. J Altern Complement Med. 2007 Jan;13(1):159–75.

Calarge CA, Zimmerman B, Xie D, Kuperman S, Schlechte JA. A cross-sectional evaluation of the effect of risperidone and selective serotonin reuptake inhibitors on bone mineral density in boys. J Clin Psychiatry. 2010 Mar;71(3):338–47.

Checkley W, Robinson CL, Baumann LM, Hansel NN, Romero KM, Pollard SL, et al. 25-hydroxy vitamin D levels are associated with childhood asthma in a population-based study in Peru. Clin Exp Allergy. 2015 Jan;45(1):273–82.

Chen K, Zhang X, Li TY, Chen L, Wei XP, Qu P, et al. Effect of vitamin A, vitamin A plus iron and multiple micronutrient-fortified seasoning powder on infectious morbidity of preschool children. Nutrition. 2011;27(4):428-34.

Craig SM, Yu F, Curtis JR, Alarcon GS, Conn DL, Jonas B, et al. Vitamin D status and its associations with disease activity and severity in African Americans with recent-onset rheumatoid arthritis. J Rheumatol. 2010;37(2):275-81.

D’Adamo E, Marcovecchio ML, Giannini C, de Giorgis T, Chiavaroli V, Chiarelli F, et al. Improved oxidative stress and cardio-metabolic status in obese prepubertal children with liver steatosis treated with lifestyle combined with Vitamin E. Free Radic Res. 2013;47(3):146-53.

Della Giustina A, Landi M, Bellini F, Bosoni M, Ferrante G, Onorari M, et al. Vitamin D, allergies and asthma: focus on pediatric patients. World Allergy Organ J. 2014;7(1):27.

Dziaman T, Gackowski D, Rozalski R, Siomek A, Szulczynski J, Zabielski R, et al. Urinary excretion rates of 8-oxoGua and 8-oxodG and antioxidant vitamins level as a measure of oxidative status in healthy, full-term newborns. Free Radic Res. 2007;41(9):997-1004.

Grant WB, Wimalawansa SJ, Holick MF, Cannell JJ, Pludowski P, Lappe JM, et al. Emphasizing the Health Benefits of Vitamin D for Those with Neurodevelopmental Disorders and Intellectual Disabilities. Nutrients. 2015;7(3):1538-64.

Holick MF. The D-lightful vitamin D for child health. JPEN J Parenter Enteral Nutr. 2012;36(1 Suppl):9S-19S.

Kang JW, Kim JH, Yoon JH, Kim CH. The association between serum vitamin D level and immunoglobulin E in Korean adolescents. Int J Pediatr Otorhinolaryngol. 2014;78(5):817-20.

Kelly HW, Van Natta ML, Covar RA, Tonascia J, Green RP, Strunk RC, et al. Effect of longterm corticosteroid use on bone mineral density in children: a prospective longitudinal assessment in the childhood Asthma Management Program (CAMP) study. Pediatrics. 2008;122(1):e53-61.

Litonjua AA. Childhood asthma may be a consequence of vitamin D deficiency. Curr Opin Allergy Clin Immunol. 2009;9(3):202-7.

Ly NP, Litonjua A, Gold DR, Celedon JC. Gut microbiota, probiotics, and vitamin D: interrelated exposures influencing allergy, asthma, and obesity? J Allergy Clin Immunol. 2011;127(5):1087-94; quiz 95-6.

Mitchell ES, Conus N, Kaput J. B vitamin polymorphisms and behavior: evidence of associations with neurodevelopment, depression, schizophrenia, bipolar disorder and cognitive decline. Neurosci Biobehav Rev. 2014;47:307-20.

Patrick RP, Ames BN. Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism. FASEB J. 2014;28(6):2398-413.

Pfeffer PE, Mann EH, Hornsby E, Chambers ES, Chen YH, Rice L, et al. Vitamin D influences asthmatic pathology through its action on diverse immunological pathways. Ann Am Thorac Soc. 2014;11 Suppl 5:S314-21.

Searing DA, Zhang Y, Murphy JR, Hauk PJ, Goleva E, Leung DY. Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use. J Allergy Clin Immunol. 2010;125(5):995-1000.

Stagi S, Bertini F, Cavalli L, Matucci-Cerinic M, Brandi ML, Falcini F. Determinants of vitamin D levels in children, adolescents, and young adults with juvenile idiopathic arthritis.J Rheumatol. 2014;41(9):1884-92.

Switzeny OJ, Mullner E, Wagner KH, Brath H, Aumuller E, Haslberger AG. Vitamin and antioxidant rich diet increases MLH1 promoter DNA methylation in DMT2 subjects. Clin Epigenetics. 2012;4(1):19.