Reversing Type 2 Diabetes with Madiha Saeed MD ABIHM

Reversing Type 2 Diabetes with Madiha Saeed MD ABIHM

We interviewed Madiha Saeed MD ABIHM about reversing type 2 diabetes with a functional-medicine approach that looks at root causes. You can watch the replay below. Please note that you will be asked to enter your email address at the 30-minute mark to finish viewing the video.


In This Webinar

In this webinar you will learn:

  • What is type 2 diabetes and what causes it?
  • What is insulin resistance, and why does it matter?
  • What are some of the signs and blood-test markers of type 2 diabetes?
  • What are optimal levels of fasting glucose and hemoglobin A1C?
  • Does inflammation play a role in type 2 diabetes?
  • What is the role of the “4 S’s” (stress, sleep, social health and spirituality)?
  • Is reversing type 2 diabetes possible?
  • Will pharmaceutical approaches reverse type 2 diabetes?
  • Is there a point of no return at which type 2 diabetes is not reversible?
  • How can a person reverse type 2 diabetes?

You can find Dr. Saeed’s presentation here.

Key Discussions

Each of these keys underscores the integration of holistic principles for achieving improved health outcomes, particularly for managing and reversing type 2 diabetes.

Affordability of Healthy Living

Healthy living can be affordable through the use of simple and inexpensive household items for cleaning and self-care, such as vinegar, baking soda, and sea salt. Dr. Saeed emphasized practical ways to reduce costs while maintaining a healthy lifestyle.

The Role of Lifestyle Changes in Managing Diabetes

Reversing type 2 diabetes requires holistic lifestyle changes, such as intermittent fasting, low-carb diets, and reducing inflammation. Addressing root causes like diet, stress, and gut health is crucial for managing and preventing diabetes effectively.

Impact of Gut Health on Overall Well-being

Maintaining a healthy gut microbiome, through a clean diet and avoiding harmful substances, is essential for overall health. Gut health affects digestion, immunity, mood, and can influence the risk of chronic diseases, including diabetes and autoimmune disorders.

Importance of Emotional and Spiritual Health

Practices such as gratitude, mindfulness, and fostering positive social relationships play a significant role in reducing stress and inflammation. Spiritual and emotional well-being can impact hormonal balance, coherence, and overall physical health.

Detoxification and Minimizing Toxin Exposure

Reducing exposure to environmental toxins and hormone disruptors through natural cleaning products and healthy dietary practices is important. Detoxification practices, along with supplements and intermittent fasting, can improve insulin sensitivity and reduce the risk of chronic diseases.

Timestamped Overview

00:00 Overcoming health issues through lifestyle changes.
10:52 Digestion and insulin, how it works.
16:18 Blood work essential to check for diabetes.
17:31 Signs of insulin resistance.
27:26 Train subconscious for positivity, Heart Math research.
28:56 Practicing gratitude for positivity and better decision-making.
38:20 Imbalanced gut microbiome can harm health.
43:14 Eat veggies, protein, fat; control blood sugar.
48:50 Intermittent fasting stabilizes insulin levels for health.
51:50 Adjunct treatments can heal and prevent diabetes.
59:39 Unknown factors may disrupt body’s microbiome balance.
01:03:07 Intermittent fasting for children to manage diabetes.
01:09:35 Eating well on budget: quality over quantity.
01:11:47 Switching to nutrient-dense foods is cost-effective.
01:17:23 Promoting affordable healthy lifestyle for better health.

About Madiha M. Saeed MD ABIHM

Madiha Saeed MD ABIHM is the Director of Education for the Documenting Hope Project. She is a board-certified integrative holistic family physician practicing in Illinois.

She graduated residency in family medicine from Indiana University School of Medicine, South Bend, and received the Resident Teacher Award from the Society of Teachers of Family Medicine in 2010.

She is a diplomate of the American Board of Integrative Holistic Medicine and holds a diploma in homeopathy from the Center for Education and Development of Clinical Homeopathy.

In 2010, Dr. Saeed joined Physicians HolisticHealth Alliance in South Bend, Indiana. As an integrative holistic family physician, Dr. Saeed witnessed the struggles each patient experienced as they sought to heal their underlying issues, and their frustration about where to begin. With her team at Physicians HolisticHealth Alliance, she was determined to get to the root of disease. She poured over hundreds of books from top professionals in holistic healing, delved into research studies, and examined the common factors in her patients’ numerous success stories.

Dr. Saeed’s enthusiasm is demonstrated in her numerous public speaking engagements and her growing social media presence as HolisticMom, MD . She has had numerous articles published in Holistic Primary Care magazine, which called Dr. Saeed “an emerging voice for the next generation of holistic physicians.” Dr. Saeed also writes for the Academy of Integrative Health and Medicine and is a member of their social media team. The AIHM has featured her in a member spotlight titled “Walking the Talk: One Member Brings Holism Everywhere She Goes.”

She is the author of the best-selling book, The Holistic Rx: Your Guide to Healing Chronic Inflammation and Disease and The Holistic Rx for Kids: Parenting Healthy Brains and Bodies in a Changing World. You can find out more about her and her practice at her website www.holisticmommd.com

Disclaimer

This webinar is not a substitute for medical advice, treatment, diagnosis, or consultation with a medical professional. It is intended for general informational purposes only and should not be relied on to make determinations related to treatment of a medical condition. Documenting Hope has not verified and does not guaranty the accuracy of the information provided in this webinar.

Still Looking for Answers?

Visit the Documenting Hope Practitioner Directory to find a practitioner near you.

Join us inside our online membership community for parents, Healing Together, where you’ll find even more healing resources, expert guidance, and a community to support you every step of your child’s healing journey.

Sources & References

Accurso, A., et al. Dietary carbohydrate restriction in type 2 diabetes mellitus and metabolic syndrome: time for a critical appraisal. Nutr Metab (Lond). 2008 Apr 8:5:9.

Acuña-Catalán, D., et al. Ketogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging mice. Cell Rep Med. 2024 Jun 18;5(6):101593.

Adebayo, O., et al. The changing face of diabetes in America. Emerg Med Clin North Am. 2014;32(2):319-27.

Aggarwal, B.B., et al. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol. 2006 May 14;71(10):1397-421.

Ai, Y., et al. The relationship between diabetes mellitus and attention deficit hyperactivity disorder: A systematic review and meta-analysis. Front Pediatr. 2022 Sep 29:10:936813.

Al-Khatib, Y., et al. Depression and Metabolic Syndrome: A Narrative Review. Cureus. 2022 Feb 12;14(2):e22153.

Al-Onaizi, M., et al. Glucose intolerance induces anxiety-like behaviors independent of obesity and insulin resistance in a novel model of nutritional metabolic stress. Nutr Neurosci. 2024 Oct;27(10):1143-1161.

Allen, B.G., et al. Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism. Redox Biol. 2014:2:963-70.

Anand, P., et al. Cancer is a preventable disease that requires major lifestyle changes. Pharm Res. 2008 Sep;25(9):2097-116.

Aucoin, M., et al. Generalized anxiety disorder and hypoglycemia symptoms improved with diet modificationCase Rep Psychiatry. 2016;2016.

Bădescu, S.V., et al. The association between Diabetes mellitus and Depression. J Med Life. 2016 Apr-Jun; 9(2): 120–125.

Bahr, L.S., et al. Ketogenic diet and fasting diet as Nutritional Approaches in Multiple Sclerosis (NAMS): protocol of a randomized controlled study. Trials. 2020 Jan 2;21(1):3.

Banerjee, S., et al. Ayurveda in changing scenario of diabetes management for developing safe and effective treatment choices for the future. J Complement Integr Med. 2015.

Basic, M., et al. Obesity: genome and environment interactions. Arh Hig Rada Toksikol. 2012;63(3):395-405.

Bernstein, R.K. Blood glucose self-monitoring by diabetic patients: refinements of procedural technique. Diabetes Care. 1979 Mar-Apr;2(2):233-6.

Bernstein, R.K. Virtually continuous euglycemia for 5 yr in a labile juvenile-onset diabetic patient under noninvasive closed-loop control. Diabetes Care. 1980 Jan-Feb;3(1):140-3.

Bipartisan Policy Center. Lots to lose how America’s health and obesity crisis threatens our economic future. Washington, D.C.: Bipartisan Policy Center,; 2012.

Blázquez, E., et al. Significance of Brain Glucose Hypometabolism, Altered Insulin Signal Transduction, and Insulin Resistance in Several Neurological Diseases. Front Endocrinol (Lausanne). 2022 May 9:13:873301.

Boison, D. New insights into the mechanisms of the ketogenic diet. Curr Opin Neurol. 2017 Apr;30(2):187-192.

Bolin K, Cawley JH. The economics of obesity. 1st ed. Amsterdam; Boston: Elsevier JAI; 2007. xxiii, 364 p.p.

Bostock, E.C.S., et al. The Current Status of the Ketogenic Diet in Psychiatry. Front Psychiatry. 2017 Mar 20:8:43.

Bradford, B.L., et al. Mitochondrial Dysfunction and Type 2 Diabetes. Science. 2005 Jan 21;307(5708):384-7.

Bradley, R., et al. Algorithm for complementary and alternative medicine practice and research in type 2 diabetes. J Altern Complement Med. 2007 Jan-Feb;13(1):159-75.

Brenton, J.N., et al. Phase II study of ketogenic diets in relapsing multiple sclerosis: safety, tolerability and potential clinical benefits. J Neurol Neurosurg Psychiatry. 2022 Jun;93(6):637-644.

Brenton, J.N., et al. Pilot study of a ketogenic diet in relapsing-remitting MS. Neurol Neuroimmunol Neuroinflamm. 2019 Apr 12;6(4):e565.

Brietzke, E., et al. Ketogenic diet as a metabolic therapy for mood disorders: Evidence and developments. Neurosci Biobehav Rev. 2018 Nov:94:11-16.

Calabrese, L., et al. Complete remission of depression and anxiety using a ketogenic diet: case series. Front Nutr. 2024 May 14:11:1396685.

Campbell, I.H., et al. Ketosis and bipolar disorder: controlled analytic study of online reports. BJPsych Open. 2019 Jul 4;5(4):e58.

Campbell, I.H., et al. The metabolic overdrive hypothesis: hyperglycolysis and glutaminolysis in bipolar mania. Mol Psychiatry. 2024 May;29(5):1521-1527.

Carlson, J.A., et al. Dietary-related and physical activity-related predictors of obesity in children: a 2-year prospective study. Child Obes. 2012;8(2):110-5.

Centers for Disease Control and Prevention. All About Your A1C.

Centers for Disease Control and Prevention. Diabetes Tests.

Centers for Disease Control and Prevention. National Diabetes Statistics Report, 2020: Estimates of Diabetes and Its Burden in the United States.

Cheng, N., et al. Metabolic Dysfunction Underlying Autism Spectrum Disorder and Potential Treatment Approaches. Front Mol Neurosci. 2017 Feb 21:10:34.

Chmiel, I. Ketogenic diet in therapy of bipolar affective disorder - case report and literature review. Psychiatr Pol. 2022 Dec 31;56(6):1345-1363.

Choquet, H., et al. Genomic insights into early-onset obesity. Genome Med. 2010;2(6):36.

Classen, J.B. Review of evidence that epidemics of type 1 diabetes and type 2 diabetes/metabolic syndrome are polar opposite responses to iatrogenic inflammation. Curr Diabetes Rev. 2012;8(6):413-8.

Coller, H.A. Is cancer a metabolic disease? Am J Pathol. 2014 Jan;184(1):4-17.

Cortese, S., et al. The Association between ADHD and Obesity: Intriguing, Progressively More Investigated, but Still Puzzling. Brain Sci. 2019 Sep 27;9(10):256.

Cortese, S., et al. Attention-deficit/hyperactivity disorder, iron deficiency, and obesity: is there a link? Postgrad Med. 2014;126(4):155-70.

Cui, J., et al. Butyrate-Producing Bacteria and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES). Diabetes. 2022 Nov 1;71(11):2438-2446.

Danan, K., et al. The Ketogenic Diet for Refractory Mental Illness: A Retrospective Analysis of 31 Inpatients. Front Psychiatry. 2022 Jul 6:13:951376.

deCampo, D.M., et al. Ketogenic dietary therapies for epilepsy and beyond. Curr Opin Clin Nutr Metab Care. 2019 Jul;22(4):264-268.

de la Rubia Orti, J.E., et al. Can Ketogenic Diet Improve Alzheimer’s Disease? Association With Anxiety, Depression, and Glutamate System. Front Nutr. 2021 Oct 27:8:744398.

de la Rubia Orti, J.E., et al. Exploring the impact of ketogenic diet on multiple sclerosis: obesity, anxiety, depression, and the glutamate system. Front Nutr. 2023 Aug 25:10:1227431.

Desai, J.R., et al. Diabetes and asthma case identification, validation, and representativeness when using electronic health data to construct registries for comparative effectiveness and epidemiologic research. Med Care. 2012;50 Suppl:S30-5.

Dietch, D.M., et al. Efficacy of low carbohydrate and ketogenic diets in treating mood and anxiety disorders: systematic review and implications for clinical practice. BJPsych Open. 2023 Apr 17;9(3):e70.

Douglas, B.L., et al. Washington Business Group on Health. Obesity an overview of an American epidemic. Washington, D.C.: Washington Business Group on Health,; 2002.

Duan, W., et al. Hyperglycemia, a neglected factor during cancer progression. Biomed Res Int. 2014:2014:461917.

Dyńka, D., et al. The Role of Ketogenic Diet in the Treatment of Neurological Diseases. Nutrients. 2022 Nov 24;14(23):5003.

Evangeliou, A., et al. Application of a ketogenic diet in children with autistic behavior: pilot study. J Child Neurol. 2003 Feb;18(2):113-8.

Feinman, R.K., et al. Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base. Nutrition. 2015 Jan;31(1):1-13.

Foster-Powell, K., et al. International table of glycemic index and glycemic load values: 2002. Am J Clin Nutr. 2002 Jul;76(1):5-56.

Freeman, C.R., et al. Impact of sugar on the body, brain, and behavior. Front Biosci (Landmark Ed). 2018 Jun 1;23(12):2255-2266.

Garcia-Argibay, M., et al. The association between type 2 diabetes and attention- deficit/hyperactivity disorder: A systematic review, meta-analysis, and population-based sibling study. Neurosci Biobehav Rev. 2023 Apr:147:105076.

Giovannucci, E., et al. Diabetes and cancer: a consensus report. Diabetes Care. 2010 Jul;33(7):1674-85.

Gough, S., et al. Neuroprotection by the Ketogenic Diet: Evidence and Controversies. Front Nutr. 2021 Nov 23:8:782657.

Grammes, J., et al. Fear of hypoglycemia in patients with type 2 diabetes: The role of interoceptive accuracy and prior episodes of hypoglycemia. J Psychosom Res. 2018;105:58-63.

Grochowska, K., et al. The Effect of the Ketogenic Diet on the Therapy of Neurodegenerative Diseases and Its Impact on Improving Cognitive Functions. Dement Geriatr Cogn Dis Extra. 2022 May 30;12(2):100-106.

Guo, D., et al. Association of maternal diabetes with attention deficit/hyperactivity disorder (ADHD) in offspring: A meta-analysis and review. Diabetes Res Clin Pract. 2020 Jul:165:108269.

Han, H., et al. Gut Microbiota and Type 1 Diabetes. Int J Mol Sci. 2018 Mar 27;19(4):995.

Hao, J., et al. Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats. J Cell Mol Med. 2009 Apr;13(4):701-11.

He, C., et al. Targeting gut microbiota as a possible therapy for diabetes. Nutr Res. 2015.

Hinzmann, R., et al. What do we need beyond hemoglobin A1c to get the complete picture of glycemia in people with diabetes? Int J Med Sci. 2012;9(8):665-81.

Hou, X., et al. A study of brain glucose metabolism in obsessive-compulsive disorder patients. Ann Palliat Med. 2022 Nov;11(11):3503-3512.

Irish, A.K., et al. Randomized control trial evaluation of a modified Paleolithic dietary intervention in the treatment of relapsing-remitting multiple sclerosis: a pilot study. Degener Neurol Neuromuscul Dis. 2017 Jan 4;7:1-18.

Jiang, Z., et al. Effects of Ketogenic Diet on Neuroinflammation in Neurodegenerative Diseases. Aging Dis. 2022 Jul 11;13(4):1146-1165.

Johnson, R.J., et al. Attention-deficit/hyperactivity disorder: is it time to reappraise the role of sugar consumption? Postgrad Med. 2011 Sep;123(5):39-49.

Kamba, A., et al. Association between higher serum cortisol levels and decreased insulin secretion in a general populationPLOS ONE. 2016;11(11):e0166077.

Kapoor, D., et al. Emerging Role of the Ketogenic Dietary Therapies beyond Epilepsy in Child Neurology. Ann Indian Acad Neurol. 2021 Jul-Aug;24(4):470-480.

Karkafi, R.E., et al. Ketogenic Diet and Inflammation: Implications for Mood and Anxiety Disorders. Adv Exp Med Biol. 2023:1411:537-554.

Kobayashi, Y., et al. Strength training is more effective than aerobic exercise for improving glycaemic control and body composition in people with normal-weight type 2 diabetes: a randomised controlled trial. Diabetologia. 2023 Oct;66(10):1897-1907.

Kogut, S.J., et al. Evaluation of a program to improve diabetes care through intensified care management activities and diabetes medication copayment reduction. J Manag Care Pharm. 2012;18(4):297-310.

Kong., A.P, et al. Diabetes and its comorbidities–where East meets West. Nat Rev Endocrinol. 2013;9(9):537-47.

Kraft, B.D., et al. Schizophrenia, gluten, and low-carbohydrate, ketogenic diets: a case report and review of the literature. Nutr Metab (Lond). 2009 Feb 26:6:10.

Krikorian, R., et al. Dietary ketosis enhances memory in mild cognitive impairment. Neurobiol Aging. 2012 Feb;33(2):425.e19-27.

Labbé, D.P., et al. Role of diet in prostate cancer: the epigenetic link. Oncogene. 2015 Sep 3;34(36):4683-91.

Laron, Z. Interplay between heredity and environment in the recent explosion of type 1 childhood diabetes mellitus. Am J Med Genet. 2002;115(1):4-7.

Laurent, N., et al. Ketogenic diets in clinical psychology: examining the evidence and implications for practice. Front Psychol. 2024 Sep 26:15:1468894.

Lee, C., et al. Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer Res. 2010 Feb 15;70(4):1564-72.

Lee, R.W.Y., et al. A modified ketogenic gluten-free diet with MCT improves behavior in children with autism spectrum disorder. Physiol Behav. 2018 May 1:188:205-211.

Lefevre, F., et al. Ketogenic diet for the treatment of refractory epilepsy in children: A systematic review of efficacy. Pediatrics. 2000 Apr;105(4):E46.

Lennerz, B.S., et al. Management of Type 1 Diabetes With a Very Low-Carbohydrate Diet.
Pediatrics. 2018 Jun;141(6):e20173349.

Levi, J., et al. F as in fat how obesity threatens America’s future : 2012. Washington, D.C.: Trust for America’s Health; 2012.

Li, Q., et al. A Ketogenic Diet and the Treatment of Autism Spectrum Disorder. Front Pediatr. 2021 May 11:9:650624.

Liu, H., et al. Refined fructose and cancer. Expert Opin Ther Targets. 2011 Sep;15(9):1049-59.

Liu, S., et al. Poor glycaemic control is associated with increased risk of neurodevelopmental disorders in childhood-onset type 1 diabetes: a population-based cohort study. Diabetologia. 2021 Apr;64(4):767-777.

Longhitano, C., et al. The effects of ketogenic metabolic therapy on mental health and metabolic outcomes in schizophrenia and bipolar disorder: a randomized controlled clinical trial protocol. Front Nutr. 2024 Aug 21:11:1444483.

Lorenzi, M., et al. High glucose induces DNA damage in cultured human endothelial cells. J Clin Invest. 1986 Jan;77(1):322-5.

Ly, N.P., et al. Gut microbiota, probiotics, and vitamin D: interrelated exposures influencing allergy, asthma, and obesity? J Allergy Clin Immunol. 2011;127(5):1087-94; quiz 95-6.

Magrone, T., et al. Childhood obesity: immune response and nutritional approaches. Front Immunol. 2015;6:76.

Mazor-Aronovitch, A., et al. Dual diagnosis of type 1 diabetes mellitus and attention deficit hyperactivity disorder. Pediatr Diabetes. 2021 Jun;22(4):649-655.

McDonald, T.J.W., et al. Ketogenic Diets for Adult Neurological Disorders. Neurotherapeutics. 2018 Oct;15(4):1018-1031.

Mentzelou, M., et al. The Relationship of Ketogenic Diet with Neurodegenerative and Psychiatric Diseases: A Scoping Review from Basic Research to Clinical Practice. Nutrients. 2023 May 11;15(10):2270.

Mierau, S.B., et al. Metabolic interventions in Autism Spectrum Disorder. Neurobiol Dis. 2019 Dec:132:104544.

Minhas, P.S., et al. Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies. Science. 2024 Aug 23;385(6711):eabm6131.

Mu, C., et al. Metabolic Framework for the Improvement of Autism Spectrum Disorders by a Modified Ketogenic Diet: A Pilot Study. J Proteome Res. 2020 Jan 3;19(1):382-390.

Murphy, P., et al. The antidepressant properties of the ketogenic diet. Biol Psychiatry. 2004 Dec 15;56(12):981-3.

Nguyen, T.T., et al. Type 3 Diabetes and Its Role Implications in Alzheimer's Disease. Int J Mol Sci. 2020 Apr 30;21(9):3165.

Noland, R.C., et al. Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. J Biol Chem. 2009 Aug 21;284(34):22840-52.

Norwitz, N.G., et al. Ketogenic diet as a metabolic treatment for mental illness. Curr Opin Endocrinol Diabetes Obes. 2020 Oct;27(5):269-274.

Olivito, I., et al. Ketogenic diet ameliorates autism spectrum disorders-like behaviors via reduced inflammatory factors and microbiota remodeling in BTBR T+ Itpr3tf/J mice. Exp Neurol. 2023 Aug:366:114432.

Omori, N.E., et al. Exploring the role of ketone bodies in the diagnosis and treatment of psychiatric disorders. Front Psychiatry. 2023 Apr 17:14:1142682.

Onodera, Y., et al. Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways. J Clin Invest. 2014 Jan;124(1):367-84.

Operta, F.F., et al. The Ketogenic Diet for the Treatment of Mood Disorders in Comorbidity With Epilepsy in Children and Adolescents. Front Pharmacol. 2020 Nov 24:11:578396.

Pacal, L., et al. Parameters of oxidative stress, DNA damage and DNA repair in type 1 and type 2 diabetes mellitus. Arch Physiol Biochem. 2011;117(4):222-30.

Pagoto, S.L., et al. Association between adult attention deficit/hyperactivity disorder and obesity in the US population. Obesity (Silver Spring). 2009 Mar;17(3):539-44.

Palmer, C.M. Ketogenic diet in the treatment of schizoaffective disorder: Two case studies. Schizophr Res. 2017 Nov:189:208-209.

Palmer, C.M., et al. The ketogenic diet and remission of psychotic symptoms in schizophrenia: Two case studies. Schizophr Res. 2019 Jun:208:439-440.

Paoli, A., et al. Ketogenic diet in neuromuscular and neurodegenerative diseases. Biomed Res Int. 2014:2014:474296.

Phelps, J.R., et al. The ketogenic diet for type II bipolar disorder. Neurocase. 2013;19(5):423-6.

Pietrzak, D., et al. The Therapeutic Role of Ketogenic Diet in Neurological Disorders. Nutrients. 2022 May 6;14(9):1952.

Pillinger, T., et al. Impaired Glucose Homeostasis in First-Episode Schizophrenia: A Systematic Review and Meta-analysis. JAMA Psychiatry. 2017 Mar 1;74(3):261-269.

Power, R.A., et al. Carnitine revisited: potential use as adjunctive treatment in diabetes. Diabetologia. 2007 Apr;50(4):824-32.

Prins, M.L., et al. Age-dependent reduction of cortical contusion volume by ketones after traumatic brain injury. J Neurosci Res. 2005 Nov 1;82(3):413-20.

Pulgaron, E.R. Childhood obesity: a review of increased risk for physical and psychological comorbidities. Clin Ther. 2013;35(1):A18-32.

Pulsifer, M.B., et al. Effects of ketogenic diet on development and behavior: preliminary report of a prospective study. Dev Med Child Neurol. 2001 May;43(5):301-6.

Rector, R.S., et al. Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model. J Hepatol. 2010 May;52(5):727-36.

Renteria, I., et al. [Factors affecting oxidative damage in obese children: an exploratory study]. Nutr Hosp. 2015;31(4):1499-503.

Robinette, L.M., et al. Fruit and vegetable intake is inversely associated with severity of inattention in a pediatric population with ADHD symptoms: the MADDY Study. Nutr Neurosci. 2023 Jun;26(6):572-581.

Rosa, J.S., et al. Altered inflammatory, oxidative, and metabolic responses to exercise in pediatric obesity and type 1 diabetes. Pediatr Diabetes. 2011;12(5):464-72.

Salzer, H.M. Relative hypoglycemia as a cause of neuropsychiatric illness. J Natl Med Assoc. 1966;58(1):12-17.

Sanchez, A., et al. Role of sugars in human neutrophilic phagocytosis. Am J Clin Nutr. 1973 Nov;26(11):1180-4.

Sanchez, M., et al. Childhood obesity: a role for gut microbiota? Int J Environ Res Public Health. 2015;12(1):162-75. J Integr Complement Med. 2023 Feb;29(2):69-79.

Sanago, F., et al. Mind- and Body-Based Interventions Improve Glycemic Control in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis. J Integr Complement Med. 2023 Feb;29(2):69-79.

Saraga, M., et al. Ketogenic diet in bipolar disorder. Bipolar Disord. 2020 Nov;22(7):765.

Sarnyai, Z., et al. Ketogenic Therapy in Serious Mental Illness: Emerging Evidence. Int J Neuropsychopharmacol. 2020 Jul 29;23(7):434-439.

Schwalfenberg, G.K. The Importance of Magnesium in Clinical Healthcare. Scientifica (Cairo). 2017:2017:4179326.

Sethi, S., et al. The Role of Ketogenic Metabolic Therapy on the Brain in Serious Mental Illness: A Review. J Psychiatr Brain Sci. 2022;7(5):e220009.

Seyfried, T.N. Cancer as a metabolic disease. Nutr Metab (Lond). 2010 Jan 27:7:7.

Seyfried, T.N. Cancer as a metabolic disease: implications for novel therapeutics. Carcinogenesis. 2014 Mar;35(3):515-27.

Seyfried, T.N., et al. Consideration of Ketogenic Metabolic Therapy as a Complementary or Alternative Approach for Managing Breast Cancer. Front Nutr. 2020 Mar 11:7:21.

Seyfried, T.N., et al. Is the restricted ketogenic diet a viable alternative to the standard of care for managing malignant brain cancer? Epilepsy Res. 2012 Jul;100(3):310-26.

Seyfried, T.N., et al. Metabolic management of brain cancer. Biochim Biophys Acta. 2011 Jun;1807(6):577-94.

Shen, W., et al. Protective effects of R-alpha-lipoic acid and acetyl-L-carnitine in MIN6 and isolated rat islet cells chronically exposed to oleic acid. J Cell Biochem. 2008 Jul 1;104(4):1232-43.

Shlomowitz, A., et al. Anxiety associated with self monitoring of capillary blood glucoseBritish Journal of Diabetes. 2014;14(2):60-63.

Smith, J., et al. Ketogenic diet restores aberrant cortical motor maps and excitation-to-inhibition imbalance in the BTBR mouse model of autism spectrum disorder. Behav Brain Res. 2016 May 1:304:67-70.

Smith, K.J., et al. Association of diabetes with anxiety: a systematic review and meta-analysisJ Psychosom Res. 2013;74(2):89-99.

Sreekumar, R., et al. Skeletal muscle mitochondrial dysfunction & diabetes. Indian J Med Res. 2007 Mar;125(3):399-410.

Stafstrom, C.E., et al. The ketogenic diet as a treatment paradigm for diverse neurological disorders. Front Pharmacol. 2012 Apr 9:3:59.

Tao, Y., et al. Ketogenic Diet: An Effective Treatment Approach for Neurodegenerative Diseases. Curr Neuropharmacol. 2022 Nov 15;20(12):2303-2319.

Tidman, M.M., et al. Effects of an low carbohydrate/healthy fat/ketogenic diet on biomarkers of health and symptoms, anxiety and depression in Parkinson's disease: a pilot study. Neurodegener Dis Manag. 2022 Apr;12(2):57-66.

Tinkum, K.L., et al. Fasting protects mice from lethal DNA damage by promoting small intestinal epithelial stem cell survival. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):E7148-54.

Townsend, L., et al. Brain glucose metabolism in schizophrenia: a systematic review and meta-analysis of 18FDG-PET studies in schizophrenia. Psychol Med. 2023 Aug;53(11):4880-4897.

Tuomi, T., et al. The many faces of diabetes: a disease with increasing heterogeneity. Lancet. 2014;383(9922):1084-94.

Vaarala, O. Is the origin of type 1 diabetes in the gut? Immunol Cell Biol. 2012;90(3):271-6.

Vaarala, O. Gut microbiota and type 1 diabetes. Rev Diabet Stud. 2012;9(4):251-9.

Vargas, D.D., et al. Effectiveness of nutritional interventions on behavioral symptomatology of autism spectrum disorder: a systematic review. Nutr Hosp. 2022 Dec 20;39(6):1378-1388.

Verberne, A.J.M., et al. Adrenaline: insights into its metabolic roles in hypoglycaemia and diabetesBr J Pharmacol. 2016;173(9):1425-1437.

Witkowski, M., et al. The artificial sweetener erythritol and cardiovascular event risk. Nat Med. 2023 Mar;29(3):710-718.

Xiang, A.H., et al. Maternal Gestational Diabetes Mellitus, Type 1 Diabetes, and Type 2 Diabetes During Pregnancy and Risk of ADHD in Offspring. Diabetes Care. 2018 Dec;41(12):2502-2508.

Xu, F., et al. Association of attention-deficit/hyperactivity disorder with diabetes mellitus in US adults. J Diabetes. 2021 Apr;13(4):299-306.

Yuan, J., et al. Regular use of proton pump inhibitors and risk of type 2 diabetes: results from three prospective cohort studies. Gut. 28 Sep 2020.

Zheng, P., et al. Gut microbiome in type 1 diabetes: A comprehensive review. Diabetes Metab Res Rev. 2018 Oct;34(7):e3043.

Zhou, H., et al. Evaluating the Causal Role of Gut Microbiota in Type 1 Diabetes and Its Possible Pathogenic Mechanisms. Front Endocrinol (Lausanne). 2020 Mar 24:11:125.

Resources
Articles

Amen, Daniel. The Surprising Role Diet Plays in ADD/ADHD Symptoms. Amen Clinics, 29 Jul 2021.

Centers for Disease Control. National Diabetes Statistics Report. Accessed 22 Oct 2024.

Mayers, Dara. The nutrition advice given to most diabetics might be killing them. U.S. News Health & Medicine, Jul 2003.

Totty, Patrick. ADA’s Latest Low-Carb Stance Is Severely Flawed, Says Longtime Low-Carb Advocate Dr. Bernstein. Diabetes Health, 8 Feb 2008.

Books

Bernstein, Richard K. Dr. Bernstein's Diabetes Solution: The Complete Guide to Achieving Normal Blood Sugars. Little, Brown Spark, 2011.

Ede, Georgia. Change Your Diet, Change Your Mind: A Powerful Plan to Improve Mood, Overcome Anxiety, and Protect Memory for a Lifetime of Optimal Mental Health. Balance, 2024.

Inchauspe, Jessie. Glucose Revolution: The Life-Changing Power of Balancing Your Blood Sugar. S&S/Simon Element, 2022.

Minger, Denise. Death by Food Pyramid: How Shoddy Science, Sketchy Politics and Shady Special Interests Have Ruined Our Health. Primal Blueprint Publishing, 2014.

Palmer, Christopher M. Brain Energy: A Revolutionary Breakthrough in Understanding Mental Health--and Improving Treatment for Anxiety, Depression, OCD, PTSD, and More. BenBella Books, 2022.

Rodgers, Diana. Sacred Cow: The Case for (Better) Meat: Why Well-Raised Meat Is Good for You and Good for the Planet. BenBella Books, 2021.

Wahls, Terry. The Wahls Protocol: A Radical New Way to Treat All Chronic Autoimmune Conditions Using Paleo Principles. Avery, 2020.

Wahls, Terry. The Wahls Protocol Cooking for Life: The Revolutionary Modern Paleo Plan to Treat All Chronic Autoimmune Conditions. Avery, 2017.

Winters, Nasha, et al. The Metabolic Approach to Cancer: Integrating Deep Nutrition, the Ketogenic Diet, and Nontoxic Bio-Individualized Therapies. Chelsea Green Publishing Co., 2017.

Websites

Amen Clinics

A*STAR’s (Agency for Science, Technology and Research) Institute of Molecular and Cell Biology (IMCB)

Chris Palmer MD

diagnosis:Diet (Georgia Ede MD)

Dr. Bernstein's Diabetes Solution

Dr Iain Campbell: Baszucki Research Fellow in Metabolic Psychiatry

Metabolic Terrain Institute of Health

Stanford Medicine: Department of Psychiatry and Behavioral Sciences: Metabolic Psychiatry Clinic

Terry Wahls MD