We will be interviewing James Greenblatt MD, the founder of Psychiatry Redefined and author of multiple books, about how functional psychiatry can lower symptoms of depression on Wednesday, July 1, 2026 at 12:00pm Eastern. Sign up below to to join us in this live interview and ask your own questions!
How Can Functional Psychiatry Help with Symptoms of Depression?
A functional-medicine approach to psychiatry means addressing root causes such as nutritional deficiencies, inflammation, toxicity, immune dysregulation, gut dysbiosis and more. James Greenblatt MD is a pioneer in this field. His book Finally Hopeful: The Personalized, Whole-Body Plan to Find and Fix the Root Causes of Your Depression, details how individualized treatment with supplements such as omega-3 fatty acids, magnesium, zinc, amino acids, polyphenols, vitamin D and certain B vitamins such as folate, thiamine and vitamin B12 can help improve symptoms of depression.
In This Expert Interview
In this interview, Dr. Greenblatt will help us to answer the following questions:
- What is functional psychiatry?
- What are common root causes of depression?
- Why should patients be tested, then treated?
- What kinds of tests are helpful to run for someone with depression?
- Which nutritional deficiencies are common for people with depression?
- What role does cholesterol play in depression?
- What role does blood-sugar dysregulation play in depression?
- What role does gut dysbiosis play in depression?
- What role does chronic inflammation play in depression?
- What kinds of dietary or lifestyle choices are helpful for people with depression?
- Is it possible to come off of antidepressants after a patient has started them? If so, how does this happen?
Join us in this live interview to ask Dr. Greenblatt to ask your own questions in this live interview!
About James Greenblatt MD
Dr. James Greenblatt, MD, is a dual board-certified psychiatrist and internationally recognized pioneer in functional and integrative psychiatry. Widely regarded as the leading expert on the clinical application of low-dose lithium for mental health, Dr. Greenblatt has spent more than 30 years advancing precision-based approaches that move beyond symptom management to address the root causes of mental illness.
“When you treat one patient, you help one patient and their family. When I train a clinician, we have the opportunity to help thousands of patients.”
This commitment to education and transformation has guided his career and shaped his global influence.
After earning his medical degree at George Washington University, Dr. Greenblatt completed his psychiatry residency there and a fellowship in Child and Adolescent Psychiatry at Johns Hopkins Medical School. He currently serves as an Assistant Clinical Professor of Psychiatry at Tufts University School of Medicine and Dartmouth College’s Geisel School of Medicine.
A prolific author, Dr. Greenblatt has written ten books, including his newest books, The Lithium Revolution and Finally Hopeful, and the bestsellers Finally Focused: The Breakthrough Natural Treatment Plan for ADHD, Answers to Anorexia (updated edition, 2021), Functional & Integrative Medicine for Antidepressant Withdrawal, and Nutritional Lithium: The Untold Tale of a Mineral That Transforms Lives and Heals the Brain—the definitive guide to lithium’s role in psychiatry.
In 2019, he founded Psychiatry Redefined, a leading educational platform training clinicians worldwide in functional and integrative psychiatry. A sought-after international speaker, Dr. Greenblatt regularly lectures on nutritional psychiatry and the transformative role of functional medicine in mental health—and is available for expert commentary, speaking engagements, and media interviews. To learn more about him and his work, go to https://www.jamesgreenblattmd.com/
Disclaimer
This expert interview is not a substitute for medical advice, treatment, diagnosis, or consultation with a medical professional. It is intended for general informational purposes only and should not be relied on to make determinations related to treatment of a medical condition. Documenting Hope has not verified and does not guaranty the accuracy of the information provided in this expert interview.
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Sources & References
Adler, U.C., et al. Homeopathic Individualized Q-Potencies versus Fluoxetine for Moderate to Severe Depression: Double-Blind, Randomized Non-Inferiority Trial. Evid Based Complement Alternat Med. 2011:2011:520182.
Al-Fartusie, F.S., et al. Evaluation of Some Trace Elements and Vitamins in Major Depressive Disorder Patients: a Case-Control Study. Biol Trace Elem Res. 2019 Jun;189(2):412-419.
Al-Khatib, Y., et al. Depression and Metabolic Syndrome: A Narrative Review. Cureus. 2022 Feb 12;14(2):e22153.
Al Maruf, M., et al. Systematic Review and Meta-Analysis of L-Methylfolate Augmentation in Depressive Disorders. Pharmacopsychiatry. 2022 May;55(3):139-147.
Anderson, J.W., et al. Private prayer associations with depression, anxiety and other health conditions: an analytical review of clinical studies. Postgrad Med. 2016 Sep;128(7):635-41.
Antao, H.S., et al. Omega-3 index as risk factor in psychiatric diseases: a narrative review. Front Psychiatry. 2023 Jul 28:14:1200403.
Asadi, S., et al. Beneficial effects of nano-curcumin supplement on depression and anxiety in diabetic patients with peripheral neuropathy: A randomized, double-blind, placebo-controlled clinical trial. Phytother Res. 2020 Apr;34(4):896-903.
Aucoin, M., et al. Major Depressive Disorder and Food Hypersensitivity: A Case Report. Neuropsychobiology. 2019 Oct 10:1-7.
Bardinet, J., et al. Patterns of polyphenol intake and risk of depressive symptomatology in a population-based cohort of older adults. Clin Nutr. 2022 Dec;41(12):2628-2636.
Barragán-Rodríguez, L., et al. Efficacy and safety of oral magnesium supplementation in the treatment of depression in the elderly with type 2 diabetes: a randomized, equivalent trial. Magnes Res. 2008 Dec;21(4):218-23.
Baughman, N., et al. The Prevention of Anxiety and Depression in Early Childhood. Front Psychol. 2020 Sep 30:11:517896.
Bayes, J., et al. Effects of Polyphenols in a Mediterranean Diet on Symptoms of Depression: A Systematic Literature Review. Adv Nutr. 2020 May 1;11(3):602-615.
Bender, A., et al. The association of folate and depression: A meta-analysis. J Psychiatr Res. 2017 Dec:95:9-18.
Berger, M.E., et al. Omega-6 to omega-3 polyunsaturated fatty acid ratio and subsequent mood disorders in young people with at-risk mental states: a 7-year longitudinal study. Transl Psychiatry. 2017 Aug 29;7(8):e1220.
Berk, M., et al. So depression is an inflammatory disease, but where does the inflammation come from? BMC Med. 2013;11:200.
Bitsko, R.H., et al. Epidemiology and Impact of Health Care Provider-Diagnosed Anxiety and Depression Among US Children. J Dev Behav Pediatr. 2018 Apr 24.
Bode, H., et al. Hyperthyroidism and clinical depression: a systematic review and meta-analysis. Transl Psychiatry. 2022 Sep 5;12(1):362.
Boelens, P.A., et al. A randomized trial of the effect of prayer on depression and anxiety. Int J Psychiatry Med. 2009;39(4):377-92.
Borges-Vieira, J.G., et al. Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials. Nutr Neurosci. 2023 Mar;26(3):187-207.
Botturi, A., et al. The Role and the Effect of Magnesium in Mental Disorders: A Systematic Review. Nutrients. 2020 Jun 3;12(6):1661.
Brownley, K.A., et al. Dietary chromium supplementation for targeted treatment of diabetes patients with comorbid depression and binge eating. Med Hypotheses. 2015 Jul;85(1):45-8.
Cox, N., et al. Ketogenic diets potentially reverse Type II diabetes and ameliorate clinical depression: A case study. Diabetes Metab Syndr. 2019 Mar-Apr;13(2):1475-1479.
Darbinyan, V., et al. Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. Nord J Psychiatry. 2007;61(5):343-8.
Davidson, J.R., et al. Homeopathic treatment of depression and anxiety. Altern Ther Health Med. 1997 Jan;3(1):46-9.
Davidson, J.R.T., et al. Effectiveness of chromium in atypical depression: a placebo-controlled trial. Biol Psychiatry. 2003 Feb 1;53(3):261-4.
Docherty, J.P., et al. A double-blind, placebo-controlled, exploratory trial of chromium picolinate in atypical depression: effect on carbohydrate craving. J Psychiatr Pract. 2005 Sep;11(5):302-14.
Fusar-Poli, L., et al. Curcumin for depression: a meta-analysis. Crit Rev Food Sci Nutr. 2020;60(15):2643-2653.
Ghazizadeh, G., et al. The effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials: A systematic review and meta-analysis. Phytother Res. 2021 Dec;35(12):6690-6705.
Hepgul, N., et al. Depression pathogenesis and treatment: what can we learn from blood mRNA expression? BMC Med. 2013;11:28.
Hidese, S., et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr. 2017 Apr;29(2):72-79.
Hintikka, J., et al. High vitamin B12 level and good treatment outcome may be associated in major depressive disorder. BMC Psychiatry. 2003 Dec 2:3:17.
Kanchanatawan, B., et al. Add-on Treatment with Curcumin Has Antidepressive Effects in Thai Patients with Major Depression: Results of a Randomized Double-Blind Placebo-Controlled Study. Neurotox Res. 2018 Apr;33(3):621-633.
Kate, N., et al. Does B12 deficiency lead to lack of treatment response to conventional antidepressants? Psychiatry (Edgmont). 2010 Nov;7(11):42-4.
Kelaiditis, C.F., et al. Effects of long-chain omega-3 polyunsaturated fatty acids on reducing anxiety and/or depression in adults; A systematic review and meta-analysis of randomised controlled trials. Prostaglandins Leukot Essent Fatty Acids. 2023 May:192:102572.
Lai, C.C.W., et al. The association between gut-health promoting diet and depression: A mediation analysis. J Affect Disord. 2023 Mar 1:324:136-142.
Lai, J., et al. The efficacy of zinc supplementation in depression: systematic review of randomised controlled trials. J Affect Disord. 2012 Jan;136(1-2):e31-e39.
Lamon-Fava, S., et al. Clinical response to EPA supplementation in patients with major depressive disorder is associated with higher plasma concentrations of pro-resolving lipid mediators. Neuropsychopharmacology. 2023 May;48(6):929-935.
Lehto, S.M., et al. Low serum HDL-cholesterol levels are associated with long symptom duration in patients with major depressive disorder. Psychiatry Clin Neurosci. 2010 Jun;64(3):279-83.
Leuchter, A.F., et al. Intermediate phenotypes and biomarkers of treatment outcome in major depressive disorder. Dialogues Clin Neurosci. 2014;16(4):525-37.
Lewis, M.D., et al. Suicide deaths of active-duty US military and omega-3 fatty-acid status: a case-control comparison. J Clin Psychiatry. 2011 Dec;72(12):1585-90.
Liao, Y., et al. Efficacy of omega-3 PUFAs in depression: A meta-analysis. Transl Psychiatry. 2019 Aug 5;9(1):190.
Li, B., et al. Dietary magnesium and calcium intake and risk of depression in the general population: A meta-analysis. Aust N Z J Psychiatry. 2017 Mar;51(3):219-229.
Li, Z., et al. Dietary zinc and iron intake and risk of depression: A meta-analysis. Psychiatry Res. 2017 May:251:41-47.
Lopresti, A.L., et al. Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study. J Affect Disord. 2017 Jan 1:207:188-196.
Maletic, V., et al. A Review of l-Methylfolate as Adjunctive Therapy in the Treatment of Major Depressive Disorder. Prim Care Companion CNS Disord. 2023 May 9;25(3):22nr03361.
Manigault, A.W., et al. Psychosocial Resilience to Inflammation-Associated Depression: A Prospective Study of Breast-Cancer Survivors. Psychol Sci. 2022 Aug;33(8):1328-1339.
McLeod, M.N., et al. Chromium treatment of depression. Int J Neuropsychopharmacol. 2000 Dec;3(4):311-314.
McNally, L., et al. Inflammation, glutamate, and glia in depression: a literature review. CNS Spectr. 2008 Jun;13(6):501-10.
Mitchell, E.S., et al. B vitamin polymorphisms and behavior: evidence of associations with neurodevelopment, depression, schizophrenia,bipolar disorder and cognitive decline. Neurosci Biobehav Rev. 2014;47:307-20.
Moabedi, M., et al. Magnesium supplementation beneficially affects depression in adults with depressive disorder: a systematic review and meta-analysis of randomized clinical trials. Front Psychiatry. 2023 Dec 22:14:1333261.
Möhler, H. The GABA system in anxiety and depression and its therapeutic potential. Neuropharmacology. 2012 Jan;62(1):42-53.
Nagayasu, Y., et al. Possible prevention of post-partum depression by intake of omega-3 polyunsaturated fatty acids and its relationship with interleukin 6. J Obstet Gynaecol Res. 2021 Apr;47(4):1371-1379.
Netz, K. Is the Comparison between Exercise and Pharmacologic Treatment of Depression in the Clinical Practice Guideline of the American College of Physicians Evidence-Based? Front Pharmacol. 2017 May 15:8:257.
Ng, Q.X., et al. Clinical Use of Curcumin in Depression: A Meta-Analysis. J Am Med Dir Assoc. 2017 Jun 1;18(6):503-508.
Nikolova, V.L., et al. Acceptability, Tolerability, and Estimates of Putative Treatment Effects of Probiotics as Adjunctive Treatment in Patients With Depression. JAMA Psychiatry. 2023 Aug 1;80(8):842-847.
O'Laoire, S. An experimental study of the effects of distant, intercessory prayer on self-esteem, anxiety, and depression. Altern Ther Health Med. 1997 Nov;3(6):38-53.
Omidian, M., et al. Effects of vitamin D supplementation on depressive symptoms in type 2 diabetes mellitus patients: Randomized placebo-controlled double-blind clinical trial. Diabetes Metab Syndr. 2019 Jul-Aug;13(4):2375-2380.
Onaolapo, A.Y., et al. Glutamate and depression: Reflecting a deepening knowledge of the gut and brain effects of a ubiquitous molecule. World J Psychiatry. 2021 Jul 19;11(7):297-315.
Papakostas, G.I., et al. L-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials. Am J Psychiatry. 2012 Dec;169(12):1267-74.
Rollins, B., et al. Mitochondrial variants in schizophrenia, bipolar disorder, and major depressive disorder. PLoS One. 2009;4(3):e4913.
Roy, T., et al. Epidemiology of depression and diabetes: a systematic review. J Affect Disord. 2012 Oct:142 Suppl:S8-21.
Salari, S., et al. Zinc sulphate: A reasonable choice for depression management in patients with multiple sclerosis: A randomized, double-blind, placebo-controlled clinical trial. Pharmacol Rep. 2015 Jun;67(3):606-9.
Shelton, R.C., et al. Assessing Effects of l-Methylfolate in Depression Management: Results of a Real-World Patient Experience Trial. Prim Care Companion CNS Disord. 2013;15(4):PCC.13m01520.
Shin, J.Y., et al. Are cholesterol and depression inversely related? A meta-analysis of the association between two cardiac risk factors. Ann Behav Med. 2008 Aug;36(1):33-43.
Simpson, C.A., et al. The gut microbiota in anxiety and depression - A systematic review. Clin Psychol Rev. 2021 Feb:83:101943.
Spedding, S. Vitamin D and depression: a systematic review and meta-analysis comparing studies with and without biological flaws. Nutrients. 2014 Apr 11;6(4):1501-18.
Steegmans, H.P., et al. Higher prevalence of depressive symptoms in middle-aged men with low serum cholesterol levels. Psychosom Med. 2000 Mar-Apr;62(2):205-11.
Styczeń, K., et al. The serum zinc concentration as a potential biological marker in patients with major depressive disorder. Metab Brain Dis. 2017 Feb;32(1):97-103.
Swann., O.G., et al. Dietary fiber and its associations with depression and inflammation. Nutr Rev. 2020 May 1;78(5):394-411.
Tan, Y., et al. Correlation between Vitamin B12 and Mental Health in Children and Adolescents: A Systematic Review and Meta-analysis. Clin Psychopharmacol Neurosci. 2023 Nov 30;21(4):617-633.
Tan, Y., et al. Review of research progress on intestinal microbiota based on metabolism and inflammation for depression. Arch Microbiol. 2024 Mar 10;206(4):146.
Tan, Y., et al. Vitamin B12, Folate, Homocysteine, Inflammatory Mediators (Interleukin-6, Tumor Necrosis Factor-α and C-Reactive Protein) Levels in Adolescents with Anxiety or Depressive Symptoms. Neuropsychiatr Dis Treat. 2023 Apr 7:19:785-800.
Tiemeier, H., et al. Vitamin B12, folate, and homocysteine in depression: the Rotterdam Study. Am J Psychiatry. 2002 Dec;159(12):2099-101.
Unno, K., et al. Improvement of Depressed Mood with Green Tea Intake. Nutrients. 2022 Jul 19;14(14):2949.
Van Meter, A.R., et al. What goes up must come down: the burden of bipolar depression in youth. J Affect Disord. 2013;150(3):1048-54.
Vashum, K.P., et al. Dietary zinc is associated with a lower incidence of depression: findings from two Australian cohorts. J Affect Disord. 2014 Sep:166:249-57.
Vignaud, P., et al. Neural effects of mindfulness-based interventions on patients with major depressive disorder: A systematic review. Neurosci Biobehav Rev. 2018 May:88:98-105.
Vilibić, M., et al. Association between total serum cholesterol and depression, aggression, and suicidal ideations in war veterans with posttraumatic stress disorder: a cross-sectional study. Croat Med J. 2014 Oct;55(5):520-9.
Wang, Y., et al. Associations between dietary intake, diet quality and depressive symptoms in youth: A systematic review of observational studies. Health Promot Perspect. 2022 Dec 10;12(3):249-265.
Wu, Y., et al. Associations of dietary B vitamins intakes with depression in adults. Int J Vitam Nutr Res. 2023 Apr;93(2):142-153.
Yaegashi, A., et al. Green Tea Consumption and Risk of Depression Symptoms: A Systematic Review and Meta-Analysis of Observational Studies. J Nutr Sci Vitaminol (Tokyo). 2022;68(3):155-161.
Yosaee, S., et al. Effects of zinc, vitamin D, and their co-supplementation on mood, serum cortisol, and brain-derived neurotrophic factor in patients with obesity and mild to moderate depressive symptoms: A phase II, 12-wk, 2 × 2 factorial design, double-blind, randomized, placebo-controlled trial. Nutrition. 2020 Mar:71:110601.
Zhang, G., et al. Thiamine nutritional status and depressive symptoms are inversely associated among older Chinese adults. J Nutr. 2013 Jan;143(1):53-8.




